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undergoes sexual
recombination resulting in shedding of a diploid
oocyst in the
environment. The oocyst undergoes meiosis to yield eight haploid
progeny known as sporozoites
(Dubey and
Frenkel 1972).
Humans may become infected by ingesting oocysts, which contaminate the
environment, or tissue cysts containing bradyzoites found in infected
meat. Despite having meiosis in its life cycle, T. gondii
maintains a
clonal
population structure.
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T. gondii
has a complex nuclear genome and two organellar
genomes. The life cycle of T. gondii has
been used in the laboratory to
cross
strains experimentally
and
to perform
linkage analysis.
Some of the advantages of this classical genetics approach include: a
relatively stable genome allows simple linkage analysis, production of a
large number of distinct progeny, haploidy simplifies genetic typing,
and allows direct observation of phenotypes, progeny can be
cryo-preserved and analyzed at a later date.
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